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D R M A N I S H
RAJPUT
ht t ps://dr manishr ajput .com
Bookan appointment!
IN T R O D U C T IO N
Dr
. Manish Rajput is an I
nterventional
Radiologist & Team Lead, Team I
R
Jaipur
. They are the biggest team of
I
nterventional Radiologists. They are
trained from Tata Memorial Center
,
Mumbai, I
ndia. They have worked in so
many government and corporate
hospitals across the country.
Medical school (MBBS):2005-2011: -People’s
Medical College, Bhopal(MP)
DNB (Radio diagnosis):
- Apollo hospital,
Hyderabad(Telangana)
FVIR (PDCC):- Tata Memorial Centre,
Mumbai(Maharashtra)
Senior Resident: Hinduja Hospital Mumbai, SMS
Hospital Jaipur
Past Visiting Doctor:Leelavati Hospital Mumbai,
Breach Candy Hospital Mumbai, Wockhardt
Hospital Mumbai, Hinduja Hospital Mumbai
Ex Assitant Professor:JNU Medical College, Jaipur
Currently Working as Senior Consultant
Interventional Radiologist in various corporate
hospitals of Rajasthan based in Jaipur
HIS
EDUCATION
S T R E N G T H S
Ilead the biggest I
R team in the state.
Vast portfolio for I
R services.
All the team members are from Tata
Memorial Hospital, Mumbai.
Extensive experience in performing and
interpreting basic Radio-Diagnosis.
Gained experience in performing
I
nterventional Radiologic procedures.
Ipossess oratory skill by speaking at
numerous industry events.
Ability to teach complex concepts in a basic
manner
.
Varicose Veins Prostate Artery Embolization PRG
Biopsy and
fNAC
Angioplasty & Venoplasty PCN & DJ Stenting
O
U
R
S
E
R
V
I
C
E
S
+91 7729021111
dr.manish@infinityintervention.com
O-5-A, Adinath Marg, Near Surya
Hospital, C Scheme, Ashok Nagar,
Jaipur, Rajasthan 302001
C ON TA C T
US!

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Dr Ankush goyal
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Acid base balance; interpretation & lines of defence by MedicoseAcademics, has 53 slides with 708 views.By Dr. Faiza Assistant Professor of Physiology MBBS (Best Graduate, AIMC Lahore), FCPS (Physiology), ICMT, CHPE, DHPE (STMU), MPH (GC University, Faisalabad), MBA (Virtual University of Pakistan) Description: This comprehensive lecture on Acid-Base Balance provides an in-depth understanding of the body’s regulatory mechanisms for maintaining pH homeostasis. Acid-base imbalances can lead to serious clinical conditions, and understanding these physiological processes is crucial for medical professionals. Learning Objectives: ✔ Compare the role of the three lines of defense in acid-base regulation ✔ Explain the role of the respiratory system in acid-base balance ✔ Describe the renal mechanisms for correcting acidosis and alkalosis ✔ Correlate acid-base disorders with their underlying etiology ✔ Interpret arterial blood gas (ABG) analysis for diagnosing acid-base imbalances ✔ Define the anion gap and explain its clinical significance Key Topics Covered: 🔹 Fundamentals of Acid-Base Chemistry – Definition of acids, bases, buffers, and the pH scale 🔹 Physiological Buffers – Bicarbonate, phosphate, and protein buffer systems 🔹 Respiratory Regulation – Role of CO₂ and ventilation in acid-base balance 🔹 Renal Regulation – HCO₃⁻ reabsorption, H⁺ secretion, and new bicarbonate generation 🔹 Acid-Base Disorders – Metabolic acidosis, metabolic alkalosis, respiratory acidosis, and respiratory alkalosis 🔹 Clinical Applications – Case studies on ABG interpretation and diagnosing acid-base imbalances Who Should Watch? ✅ Medical students (MBBS, BDS) ✅ Postgraduate trainees in Physiology, Medicine, and Critical Care ✅ Medical educators seeking a structured approach to teaching acid-base balance ✅ Healthcare professionals interested in mastering ABG interpretation 📌 Includes real-life clinical case discussions, ABG interpretation exercises, and graphical illustrations for better understanding. 📥 Download Now & Enhance Your Understanding of Acid-Base Homeostasis!
Acid base balance; interpretation & lines of defenceAcid base balance; interpretation & lines of defence
Acid base balance; interpretation & lines of defence
MedicoseAcademics
53 slides708 views
Good Laboratory Practices (GLP) Ensuring Quality and Compliance.pptx by Dr. Smita Kumbhar, has 53 slides with 127 views.Good Laboratory Practices (GLP): Ensuring Quality and Compliance Good Laboratory Practices (GLP) is a set of principles intended to ensure the quality, integrity, and reliability of non-clinical laboratory studies that support research and regulatory submissions. These guidelines are critical in the pharmaceutical, biotechnological, chemical, and environmental sectors, ensuring that laboratory-generated data are reproducible, credible, and internationally accepted. GLP standards primarily apply to safety studies involving pharmaceuticals, pesticides, food additives, and industrial chemicals. Regulatory agencies, including the USFDA, EMA, and OECD, enforce GLP compliance to maintain scientific rigor and public safety. USFDA GLP Regulations The U.S. Food and Drug Administration (USFDA) established Good Laboratory Practice regulations under 21 CFR Part 58. These regulations outline responsibilities for study directors, testing facilities, and personnel to maintain quality and integrity in non-clinical laboratory studies. The regulations cover various aspects, including study conduct, reporting, and archiving, ensuring consistency and accuracy in laboratory research. Controlling the GLP Inspection Process Regulatory authorities conduct inspections to verify GLP compliance. Laboratories must prepare for inspections by: • Maintaining up-to-date documentation. • Conducting internal audits. • Ensuring personnel training and awareness. • Implementing corrective actions for non-compliance. Regulatory inspections typically assess laboratory infrastructure, personnel competence, study documentation, and adherence to protocols. Laboratories must demonstrate transparency and proactive quality control measures. Documentation in GLP Accurate and comprehensive documentation is crucial in GLP compliance. Key documentation elements include: • Study protocols • Standard operating procedures (SOPs) • Raw data records • Analytical reports • Audit reports • Equipment calibration records • Archiving and retention policies Proper documentation ensures traceability, accountability, and reliability in laboratory research. Audit in GLP Compliance Auditing is a critical component of GLP, ensuring adherence to established regulations and identifying areas for improvement. Audits can be internal (self-audit) or external (regulatory or third-party audits). Goals of Laboratory Quality Audit • Ensure compliance with GLP regulations. • Identify gaps and areas for improvement. • Validate data integrity and accuracy. • Enhance operational efficiency. • Prevent regulatory penalties and study disqualification. Audit Tools in GLP Laboratories use various audit tools to assess compliance, including: • Checklists and self-assessments • Internal quality audits • Electronic data tracking systems • Third-party inspections • Root cause analysis • Corrective and preventive action (CAPA) plans Future of GLP Regulations
Good Laboratory Practices (GLP) Ensuring Quality and Compliance.pptxGood Laboratory Practices (GLP) Ensuring Quality and Compliance.pptx
Good Laboratory Practices (GLP) Ensuring Quality and Compliance.pptx
Dr. Smita Kumbhar
53 slides127 views
Improving the Patient Experience in Geographic Atrophy: Are You Putting the L... by PVI, PeerView Institute for Medical Education, has 53 slides with 74 views.Chair, Eleonora Lad, MD, PhD, discusses geographic atrophy in this CME/COPE/IPCE activity titled “Improving the Patient Experience in Geographic Atrophy: Are You Putting the Latest Advances Into Practice?.” For the full presentation, downloadable Practice Aids, and complete CME/COPE/IPCE information, and to apply for credit, please visit us at https://bit.ly/49lZvbL. CME/COPE/IPCE credit will be available until March 20, 2026.
Improving the Patient Experience in Geographic Atrophy: Are You Putting the L...Improving the Patient Experience in Geographic Atrophy: Are You Putting the L...
Improving the Patient Experience in Geographic Atrophy: Are You Putting the L...
PVI, PeerView Institute for Medical Education
53 slides74 views
Drugs used in the management of COPD.pptx by SivaGanesh552177, has 8 slides with 288 views.The title "Drugs Used in the Management of COPD" is covered under Unit I of the Pharmacology of Drugs Acting on the Respiratory System, Which is included in the course of Pharmacology III with Course Code BP602.
Drugs used in the management of COPD.pptxDrugs used in the management of COPD.pptx
Drugs used in the management of COPD.pptx
SivaGanesh552177
8 slides288 views
Integumentary System By Baasir Umair.pdf by Baasir Umair Khattak, has 78 slides with 24 views.The integumentary system is the largest organ system of the human body, serving as the body's first line of defense against environmental hazards. It includes the skin, hair, nails, glands, and sensory receptors. This system plays a vital role in protection, thermoregulation, sensation, excretion, and vitamin D synthesis. Understanding its structure and function is crucial for comprehending how the body interacts with its surroundings. Structure of the Integumentary System The integumentary system comprises two main components: The Skin (Cutaneous Membrane) Accessory Structures (Hair, Nails, and Glands) The Skin The skin, also called the cutaneous membrane, consists of three primary layers: 1. Epidermis The epidermis is the outermost layer of the skin, composed of stratified squamous epithelium. It lacks blood vessels and is primarily made of keratinocytes, which produce the protective protein keratin. Other important cells in the epidermis include: Melanocytes – produce melanin, which protects against UV radiation. Langerhans cells – involved in immune response. Merkel cells – associated with sensory neurons for touch perception. The epidermis has five distinct layers (from deep to superficial): Stratum basale (germinativum) – contains basal cells responsible for generating new keratinocytes. Stratum spinosum – provides structural integrity. Stratum granulosum – where keratinization begins. Stratum lucidum – found only in thick skin (palms and soles). Stratum corneum – the outermost layer made of dead keratinized cells. 2. Dermis The dermis is the thicker, connective tissue layer beneath the epidermis. It consists of collagen and elastic fibers, providing strength and flexibility. The dermis has two layers: Papillary Layer – composed of loose areolar connective tissue; contains dermal papillae, capillaries, and sensory receptors. Reticular Layer – made of dense irregular connective tissue; contains sweat glands, hair follicles, and blood vessels. 3. Hypodermis (Subcutaneous Layer) The hypodermis is a layer of adipose and connective tissue that insulates the body, stores energy, and provides cushioning. It connects the skin to underlying muscles and bones. Functions of the Integumentary System The skin performs several essential functions, including: 1. Protection The skin acts as a physical barrier against microorganisms, dehydration, UV radiation, and harmful chemicals. The acid mantle (low pH) of the skin inhibits bacterial growth. 2. Thermoregulation The skin helps maintain body temperature through: Sweating (eccrine and apocrine glands) – evaporative cooling. Vasodilation – blood vessels widen to release heat. Vasoconstriction – blood vessels narrow to retain heat. Goosebumps (arrector pili muscles) – create an insulating layer. 3. Sensation The skin contains specialized sensory receptors: Meissner’s corpuscles – detect light touch. Pacinian corpuscles – sense deep pressure and vibration. Merkel cells –
Integumentary System By Baasir Umair.pdfIntegumentary System By Baasir Umair.pdf
Integumentary System By Baasir Umair.pdf
Baasir Umair Khattak
78 slides24 views
antiherpes acyclovir mcq ANKUSH GOYAL GMC PATIALA.docx by Dr Ankush goyal, has 12 slides with 24 views.### **Acyclovir and Anti-Herpes Medications** **Acyclovir** is an antiviral medication used to treat infections caused by herpes viruses, including: - **Herpes simplex virus (HSV-1 & HSV-2)** – Causes cold sores and genital herpes. - **Varicella-zoster virus (VZV)** – Causes chickenpox and shingles. ### **Mechanism of Action:** Acyclovir works by inhibiting viral DNA replication. It is activated inside virus-infected cells, where it blocks viral enzymes, preventing the virus from multiplying. ### **Forms & Dosage:** - **Oral (Tablets/Capsules/Liquid)** – Used for mild to moderate infections. - **Topical (Cream/Ointment)** – For cold sores and mild skin infections. - **Intravenous (IV)** – For severe infections like herpes encephalitis. ### **Other Anti-Herpes Medications:** - **Valacyclovir (Valtrex)** – A prodrug of acyclovir with better absorption. - **Famciclovir (Famvir)** – Another antiviral with a longer duration of action. - **Penciclovir (Denavir)** – Used topically for herpes labialis (cold sores). ### **Uses:** - Treats and manages outbreaks of herpes simplex. - Reduces the severity and duration of symptoms. - Used for long-term suppression to prevent recurrent infections. - Helps in managing shingles and chickenpox. ### **Side Effects:** - Nausea, vomiting, diarrhea. - Headache, dizziness, fatigue. - Rare: Kidney issues, allergic reactions. ### **Precautions:** - Drink plenty of fluids to prevent kidney issues. - Not a cure, but helps manage symptoms. - Safe for most patients but should be used cautiously in people with kidney disease or weakened immune systems.
antiherpes acyclovir mcq ANKUSH GOYAL GMC PATIALA.docxantiherpes acyclovir mcq ANKUSH GOYAL GMC PATIALA.docx
antiherpes acyclovir mcq ANKUSH GOYAL GMC PATIALA.docx
Dr Ankush goyal
12 slides24 views
Understanding-Seizures-and-Epilepsy-Management.pptx by Dr Ankush goyal, has 8 slides with 89 views.Epilepsy and Its Management Introduction Epilepsy is a chronic neurological disorder characterized by recurrent, unprovoked seizures. It affects millions of people worldwide, cutting across all age groups and ethnicities. Seizures result from excessive and abnormal cortical nerve cell activity in the brain, leading to temporary changes in movement, sensation, behavior, or consciousness. This document provides a comprehensive overview of epilepsy, including its causes, classification, symptoms, diagnosis, and management strategies. Causes of Epilepsy Epilepsy can arise due to multiple factors, including genetic predisposition, brain injuries, infections, or developmental disorders. Some common causes include: Genetic Factors: Certain types of epilepsy have a hereditary component, suggesting that genetic mutations may contribute to its development. Brain Trauma: Head injuries from accidents or sports activities can lead to epilepsy. Stroke and Vascular Diseases: Stroke, which reduces oxygen supply to the brain, is a leading cause of epilepsy in older adults. Infections: Conditions such as meningitis, encephalitis, and neurocysticercosis can trigger epilepsy. Developmental Disorders: Disorders such as autism and neurofibromatosis have been linked to epilepsy. Tumors and Structural Abnormalities: Brain tumors and congenital malformations can also lead to epileptic seizures. Classification of Epilepsy The International League Against Epilepsy (ILAE) classifies epilepsy based on the nature of seizures and their origin in the brain: Focal (Partial) Seizures: Originate in one part of the brain and can be simple (without loss of consciousness) or complex (with impaired consciousness). Generalized Seizures: Involve both hemispheres of the brain and include types such as absence, tonic-clonic, myoclonic, and atonic seizures. Unknown Onset Seizures: When the starting point of the seizure is unclear. Epilepsy Syndromes: Specific syndromes such as Lennox-Gastaut syndrome, Dravet syndrome, and Juvenile Myoclonic Epilepsy have distinct features and management strategies. Symptoms of Epilepsy The clinical manifestations of epilepsy depend on the type of seizure and the brain region involved. Symptoms may include: Temporary confusion or staring spells Uncontrollable jerking movements (convulsions) Loss of consciousness or awareness Sensory disturbances such as tingling or hallucinations Emotional changes, anxiety, or déjà vu Diagnosis of Epilepsy A thorough medical evaluation is necessary to diagnose epilepsy accurately. The diagnostic process includes: Medical History and Physical Examination: A detailed history of seizure episodes, triggers, and associated conditions is crucial. Electroencephalogram (EEG): Measures electrical activity in the brain and identifies abnormal patterns suggestive of epilepsy. Neuroimaging (MRI, CT Scan): Detects structural abnormalities, tumors, or brain injuries. Blood Tests: Helps rule out metabolic or i
Understanding-Seizures-and-Epilepsy-Management.pptxUnderstanding-Seizures-and-Epilepsy-Management.pptx
Understanding-Seizures-and-Epilepsy-Management.pptx
Dr Ankush goyal
8 slides89 views
Anatomy of the Tongue by Baasir Umair.pptx by Baasir Umair Khattak, has 48 slides with 198 views.Anatomy and Nervous Supply of the Tongue Presentation Overview This PowerPoint presentation provides a detailed anatomical and neurovascular description of the tongue, covering: • General Anatomy (Structure, Location, and Parts) • Muscle Classification (Intrinsic & Extrinsic) • Papillae of the Tongue (Types & Functions) • Arterial and Venous Drainage • Lymphatic Supply • Nervous Supply (Motor & Sensory) • Development of the Tongue • Clinical Correlations This presentation is designed for medical students, professionals, and anatomy enthusiasts to enhance their understanding of the tongue's anatomy and functions. 1. Anatomy of the Tongue The tongue is a muscular organ located in the oral cavity, primarily responsible for taste, speech, mastication, and deglutition. It is covered with mucosa, containing numerous taste buds and papillae that contribute to its sensory functions. 1.1 Location of the Tongue • The tongue extends from the hyoid bone in the center of the neck to the floor of the mouth. • It is attached posteriorly to the styloid process and the soft palate. • Inferiorly, it connects to the mandible and hyoid bone. 2. Parts of the Tongue The tongue is divided into three main parts: 1. Tip (Apex): The most anterior and mobile part. 2. Body: The central region, covered with papillae and taste buds. o The ventral (inferior) surface is smooth and connected to the lingual frenulum. o The dorsal (superior) surface is rough and interacts with the palate. 3. Base (Root): The most posterior part, housing lingual tonsils and foliate papillae. Divisions of the Tongue • The sulcus terminalis divides the tongue into: o Anterior 2/3 (Oral Part) o Posterior 1/3 (Pharyngeal Part) • The foramen cecum, a small depression, marks the embryological remnant of the thyroglossal duct. 3. Papillae of the Tongue The dorsal surface of the tongue contains four types of papillae, responsible for taste and sensation: 3.1 Circumvallate Papillae • Largest in size but least numerous. • Located anterior to the sulcus terminalis. • Contain taste buds and are innervated by the Glossopharyngeal Nerve (CN IX), despite being in the anterior 2/3 region. 3.2 Fungiform Papillae • Mushroom-shaped, scattered on the anterior 2/3 of the tongue. • Contain taste buds. • Innervated by the Facial Nerve (CN VII) via Chorda Tympani. 3.3 Foliate Papillae • Located on the posterolateral sides of the tongue. • Contain taste buds. 3.4 Filiform Papillae • Most numerous but do not contain taste buds. • Provide mechanical function by enhancing friction between food and the tongue. 4. Muscles of the Tongue The tongue consists of two muscle groups: 4.1 Intrinsic Muscles (Shape and Movement) • Superior Longitudinal • Inferior Longitudinal • Transverse • Vertical 4.2 Extrinsic Muscles (Positioning and Function) • Genioglossus • Hyoglossus • Styloglossus • Palatoglossus Each muscle has a specific origin, insertion, course, and function that aids in swallowing, articulation, and movement of the tongue.
Anatomy of the Tongue by Baasir Umair.pptxAnatomy of the Tongue by Baasir Umair.pptx
Anatomy of the Tongue by Baasir Umair.pptx
Baasir Umair Khattak
48 slides198 views
Acid base balance; interpretation & lines of defence by MedicoseAcademics, has 53 slides with 708 views.By Dr. Faiza Assistant Professor of Physiology MBBS (Best Graduate, AIMC Lahore), FCPS (Physiology), ICMT, CHPE, DHPE (STMU), MPH (GC University, Faisalabad), MBA (Virtual University of Pakistan) Description: This comprehensive lecture on Acid-Base Balance provides an in-depth understanding of the body’s regulatory mechanisms for maintaining pH homeostasis. Acid-base imbalances can lead to serious clinical conditions, and understanding these physiological processes is crucial for medical professionals. Learning Objectives: ✔ Compare the role of the three lines of defense in acid-base regulation ✔ Explain the role of the respiratory system in acid-base balance ✔ Describe the renal mechanisms for correcting acidosis and alkalosis ✔ Correlate acid-base disorders with their underlying etiology ✔ Interpret arterial blood gas (ABG) analysis for diagnosing acid-base imbalances ✔ Define the anion gap and explain its clinical significance Key Topics Covered: 🔹 Fundamentals of Acid-Base Chemistry – Definition of acids, bases, buffers, and the pH scale 🔹 Physiological Buffers – Bicarbonate, phosphate, and protein buffer systems 🔹 Respiratory Regulation – Role of CO₂ and ventilation in acid-base balance 🔹 Renal Regulation – HCO₃⁻ reabsorption, H⁺ secretion, and new bicarbonate generation 🔹 Acid-Base Disorders – Metabolic acidosis, metabolic alkalosis, respiratory acidosis, and respiratory alkalosis 🔹 Clinical Applications – Case studies on ABG interpretation and diagnosing acid-base imbalances Who Should Watch? ✅ Medical students (MBBS, BDS) ✅ Postgraduate trainees in Physiology, Medicine, and Critical Care ✅ Medical educators seeking a structured approach to teaching acid-base balance ✅ Healthcare professionals interested in mastering ABG interpretation 📌 Includes real-life clinical case discussions, ABG interpretation exercises, and graphical illustrations for better understanding. 📥 Download Now & Enhance Your Understanding of Acid-Base Homeostasis!
Acid base balance; interpretation & lines of defenceAcid base balance; interpretation & lines of defence
Acid base balance; interpretation & lines of defence
MedicoseAcademics
53 slides708 views
Good Laboratory Practices (GLP) Ensuring Quality and Compliance.pptx by Dr. Smita Kumbhar, has 53 slides with 127 views.Good Laboratory Practices (GLP): Ensuring Quality and Compliance Good Laboratory Practices (GLP) is a set of principles intended to ensure the quality, integrity, and reliability of non-clinical laboratory studies that support research and regulatory submissions. These guidelines are critical in the pharmaceutical, biotechnological, chemical, and environmental sectors, ensuring that laboratory-generated data are reproducible, credible, and internationally accepted. GLP standards primarily apply to safety studies involving pharmaceuticals, pesticides, food additives, and industrial chemicals. Regulatory agencies, including the USFDA, EMA, and OECD, enforce GLP compliance to maintain scientific rigor and public safety. USFDA GLP Regulations The U.S. Food and Drug Administration (USFDA) established Good Laboratory Practice regulations under 21 CFR Part 58. These regulations outline responsibilities for study directors, testing facilities, and personnel to maintain quality and integrity in non-clinical laboratory studies. The regulations cover various aspects, including study conduct, reporting, and archiving, ensuring consistency and accuracy in laboratory research. Controlling the GLP Inspection Process Regulatory authorities conduct inspections to verify GLP compliance. Laboratories must prepare for inspections by: • Maintaining up-to-date documentation. • Conducting internal audits. • Ensuring personnel training and awareness. • Implementing corrective actions for non-compliance. Regulatory inspections typically assess laboratory infrastructure, personnel competence, study documentation, and adherence to protocols. Laboratories must demonstrate transparency and proactive quality control measures. Documentation in GLP Accurate and comprehensive documentation is crucial in GLP compliance. Key documentation elements include: • Study protocols • Standard operating procedures (SOPs) • Raw data records • Analytical reports • Audit reports • Equipment calibration records • Archiving and retention policies Proper documentation ensures traceability, accountability, and reliability in laboratory research. Audit in GLP Compliance Auditing is a critical component of GLP, ensuring adherence to established regulations and identifying areas for improvement. Audits can be internal (self-audit) or external (regulatory or third-party audits). Goals of Laboratory Quality Audit • Ensure compliance with GLP regulations. • Identify gaps and areas for improvement. • Validate data integrity and accuracy. • Enhance operational efficiency. • Prevent regulatory penalties and study disqualification. Audit Tools in GLP Laboratories use various audit tools to assess compliance, including: • Checklists and self-assessments • Internal quality audits • Electronic data tracking systems • Third-party inspections • Root cause analysis • Corrective and preventive action (CAPA) plans Future of GLP Regulations
Good Laboratory Practices (GLP) Ensuring Quality and Compliance.pptxGood Laboratory Practices (GLP) Ensuring Quality and Compliance.pptx
Good Laboratory Practices (GLP) Ensuring Quality and Compliance.pptx
Dr. Smita Kumbhar
53 slides127 views
Integumentary System By Baasir Umair.pdf by Baasir Umair Khattak, has 78 slides with 24 views.The integumentary system is the largest organ system of the human body, serving as the body's first line of defense against environmental hazards. It includes the skin, hair, nails, glands, and sensory receptors. This system plays a vital role in protection, thermoregulation, sensation, excretion, and vitamin D synthesis. Understanding its structure and function is crucial for comprehending how the body interacts with its surroundings. Structure of the Integumentary System The integumentary system comprises two main components: The Skin (Cutaneous Membrane) Accessory Structures (Hair, Nails, and Glands) The Skin The skin, also called the cutaneous membrane, consists of three primary layers: 1. Epidermis The epidermis is the outermost layer of the skin, composed of stratified squamous epithelium. It lacks blood vessels and is primarily made of keratinocytes, which produce the protective protein keratin. Other important cells in the epidermis include: Melanocytes – produce melanin, which protects against UV radiation. Langerhans cells – involved in immune response. Merkel cells – associated with sensory neurons for touch perception. The epidermis has five distinct layers (from deep to superficial): Stratum basale (germinativum) – contains basal cells responsible for generating new keratinocytes. Stratum spinosum – provides structural integrity. Stratum granulosum – where keratinization begins. Stratum lucidum – found only in thick skin (palms and soles). Stratum corneum – the outermost layer made of dead keratinized cells. 2. Dermis The dermis is the thicker, connective tissue layer beneath the epidermis. It consists of collagen and elastic fibers, providing strength and flexibility. The dermis has two layers: Papillary Layer – composed of loose areolar connective tissue; contains dermal papillae, capillaries, and sensory receptors. Reticular Layer – made of dense irregular connective tissue; contains sweat glands, hair follicles, and blood vessels. 3. Hypodermis (Subcutaneous Layer) The hypodermis is a layer of adipose and connective tissue that insulates the body, stores energy, and provides cushioning. It connects the skin to underlying muscles and bones. Functions of the Integumentary System The skin performs several essential functions, including: 1. Protection The skin acts as a physical barrier against microorganisms, dehydration, UV radiation, and harmful chemicals. The acid mantle (low pH) of the skin inhibits bacterial growth. 2. Thermoregulation The skin helps maintain body temperature through: Sweating (eccrine and apocrine glands) – evaporative cooling. Vasodilation – blood vessels widen to release heat. Vasoconstriction – blood vessels narrow to retain heat. Goosebumps (arrector pili muscles) – create an insulating layer. 3. Sensation The skin contains specialized sensory receptors: Meissner’s corpuscles – detect light touch. Pacinian corpuscles – sense deep pressure and vibration. Merkel cells –
Integumentary System By Baasir Umair.pdfIntegumentary System By Baasir Umair.pdf
Integumentary System By Baasir Umair.pdf
Baasir Umair Khattak
78 slides24 views

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